Croceic acid

Modify Date: 2024-01-02 23:53:39

Croceic acid structure	Common Name	Croceic acid
	CAS Number	27876-94-4	Molecular Weight	328.402
	Density	1.1±0.1 g/cm3	Boiling Point	585.1±23.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₄O₄	Melting Point	285°
	MSDS	N/A	Flash Point	321.7±19.1 °C

Use of Croceic acid

Transcrocetin (trans-Crocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.

Name	Crocetin
Synonym	More Synonyms

Description	Transcrocetin (trans-Crocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	NMDA receptor[1]
In Vitro	Transcrocetin (trans-Crocetin), a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 µM) reveal no negative significant changes in cellular viability. Transcrocetin at 10 µM level does not change viability while higher concentrations (40-160 µM) reduces significantly cellular viability[1].
Cell Assay	Cytotoxicity of test compounds is determined by MTT assay using Caco-2 cells in 96 well plates at a density of 20.000 cells per well in 200 µl FBS-free medium, grown for 96 h and followed by 24 h contact time with the test compounds (100 µL of serum-free media containing SE 0.5, 1, and 2 mg/mL; trans-crocin-1 250, 500, and 1000 µM; Transcrocetin 10, 40, 80, and 160 µM) and incubation at 37°C/5% CO2. The incubation solutions are aspirated, each well is washed twice with 150 µL of PBS and 50 µL of MTT solution are added (2.5 mg/mL in PBS). Supernatants are discarded and the formed formazan is dissolved in 50 µL of DMSO. The absorption of the resulting solution is determined at λ=492 nm against reference wavelength λ=690 nm[1].
References	[1]. Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44.

Density	1.1±0.1 g/cm3
Boiling Point	585.1±23.0 °C at 760 mmHg
Melting Point	285°
Molecular Formula	C₂₀H₂₄O₄
Molecular Weight	328.402
Flash Point	321.7±19.1 °C
Exact Mass	328.167450
PSA	74.60000
LogP	4.72
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.559
Storage condition	-20℃

Crocin

CAS#:42553-65-1

Croceic acid

CAS#:27876-94-4

Literature: RIKEN VITAMIN CO., LTD. Patent: WO2004/78695 A1, 2004 ; Location in patent: Page 16 ;

1-ethyl 16-(2-f...

CAS#:35482-80-5

Croceic acid

CAS#:27876-94-4

Literature: Schwieter,U. et al. Helvetica Chimica Acta, 1971 , vol. 54, p. 2447 - 2459

8,8'-Diapo-y,y-carotenedioic Acid

transcrocetin

2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, (2E,4E,6E,8E,10E,12E,14E)-

trans-Crocetin

carotenoid dicarboxylic acid

(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-Tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioic acid

8,8'-Diapocarotene-8,8'-dioic acid

all-trans-8,8'-diapocarotene-8,8'-dioic acid

Crocetin

Natural yellow 6

(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-Tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioic acid

8,8'-Diapo-8,8'-carotenedioic acid

8,8'-Diapocarotenedioic acid

EINECS 248-708-0

FEMA 2998

BioBioPha
China
Product Name: Crocetin
Price: ￥500.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Croceic acid
Price: ￥2588.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Transcrocetin
Price: $550.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-8,8'-DIAPOCAROTENEDIOIC ACID
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Croceic acid

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