SWTX-143

Modify Date: 2024-01-08 08:52:17

SWTX-143 Structure
SWTX-143 structure
 Common Name SWTX-143
CAS Number 2766575-48-6 Molecular Weight 361.36
Density N/A Boiling Point N/A
Molecular Formula C19H18F3N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SWTX-143


SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].

 Names

Name SWTX-143

 SWTX-143 Biological Activity

Description SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].
Related Catalog
References

[1]. Hanne Hillen, et al. A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models. Mol Cancer Ther. 2023 Sep 23.  

 Chemical & Physical Properties

Molecular Formula C19H18F3N3O
Molecular Weight 361.36
InChIKey YZNSUDZUJLMKNI-UHFFFAOYSA-N
SMILES C=CC(=O)NC1Cc2c(N)cccc2N(c2ccc(C(F)(F)F)cc2)C1
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Chemsrc provides SWTX-143(CAS#:2766575-48-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SWTX-143 are included as well.>> amp version: SWTX-143

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