SWTX-143

Names

[ Name ]:
SWTX-143

Biological Activity

[Description]:

SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> YAP

[References]

[1]. Hanne Hillen, et al. A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models. Mol Cancer Ther. 2023 Sep 23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₈F₃N₃O

[ Molecular Weight ]:
361.36

Related Compounds

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