Anti-osteoporosis agent-1

Modify Date: 2024-01-10 17:02:59

Anti-osteoporosis agent-1 structure	Common Name	Anti-osteoporosis agent-1
	CAS Number	2761577-50-6	Molecular Weight	354.83
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₉ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Anti-osteoporosis agent-1

Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC50=18 µM) [1].

Name	Anti-osteoporosis agent-1

Description	Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC50=18 µM) [1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology
In Vitro	Anti-osteoporosis agent-1 is an active molecule which showed effective mineralisation of osteoblast cells and up regulates the osteogenic marker gene such as Bmp-2, Runx-2 and Type-1col at both transcriptional and translational level. Besides exhibiting potential osteogenic activity. In addition, Anti-osteoporosis agent-1 also own significant anti-apoptotic activity at 1 pM &100 pM concentration and increases the osteoblast survival in serum deprived conditions[1].
References	[1]. Kriti Sharma, et al. Pyrazoline analogues: Design, synthesis, and evaluation of anti-osteoporosis activity. Bioorg Med Chem Lett. 2022 Mar 15; 60:128585.

Molecular Formula	C₂₀H₁₉ClN₂O₂
Molecular Weight	354.83