Anti-virus agent 1

Modify Date: 2024-01-08 17:05:35

Anti-virus agent 1 Structure
Anti-virus agent 1 structure
Common Name Anti-virus agent 1
CAS Number 1911578-83-0 Molecular Weight 560.50
Density N/A Boiling Point N/A
Molecular Formula C24H29N6O8P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Anti-virus agent 1


Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV)[1][2].

 Names

Name Anti-virus agent 1

 Anti-virus agent 1 Biological Activity

Description Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV)[1][2].
Related Catalog
In Vitro Anti-virus agent 1 (compound 4i) has antiviral activity for EBOV in HeLa cell (EC50=1845 nM), HMVEC cell (TERT-immortalized human foreskin microvascular endothelial cells; ATCC-4025; EC50=367 nM), human macrophages (EC50=297 nM). Anti-virus agent 1 has a CC50 of 21 μM in MT4 cell (human leukemia T-cell)[1].
References

[1]. Dustin Siegel , et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661.

[2]. Michael O' Neil Hanrahan Clarke, et al.Methods for treating arenaviridae and coronaviridae virus infections. US20170071964A1.

 Chemical & Physical Properties

Molecular Formula C24H29N6O8P
Molecular Weight 560.50