MS934
Modify Date: 2025-09-18 19:10:38
MS934 structure
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Common Name | MS934 | ||
|---|---|---|---|---|
| CAS Number | 2756323-15-4 | Molecular Weight | 1104.127 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C52H69F3In7O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MS934MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 displays antiproliferation potency against HT29 cell with GI50 of 23 nM, degrades MEK1 and MEK2 and inhibits pMEK and pERK in a concentration-dependent manner in HT-29 and SK-MEL-28 cells. |
| Name | MS934 |
|---|
| Description | MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 displays antiproliferation potency against HT29 cell with GI50 of 23 nM, degrades MEK1 and MEK2 and inhibits pMEK and pERK in a concentration-dependent manner in HT-29 and SK-MEL-28 cells. |
|---|---|
| References | 1. Jianping Hu, et al. J Med Chem. 2020 Dec 24;63(24):15883-15905. |
| Molecular Formula | C52H69F3In7O6S |
|---|---|
| Molecular Weight | 1104.127 |
| InChIKey | DYLGPTDXXUWFMK-ARFQKLFXSA-N |
| SMILES | Cc1ncsc1-c1ccc(C(C)NC(=O)C2CC(O)CN2C(=O)C(NC(=O)CCCCCCCCCCCNCCCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)C(C)(C)C)cc1 |