MS934

Names

[ Name ]:
MS934

Biological Activity

[Description]:

MS934 (MS-934) is a VHL-recruiting MEK1/2 degrader (PROTAC) with HT29 DC50 of 18/9 nM for MEK1/2 degradation, respectively.MS934 displays antiproliferation potency against HT29 cell with GI50 of 23 nM, degrades MEK1 and MEK2 and inhibits pMEK and pERK in a concentration-dependent manner in HT-29 and SK-MEL-28 cells.

[References]

1. Jianping Hu, et al. J Med Chem. 2020 Dec 24;63(24):15883-15905.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₂H₆₉F₃In₇O₆S

[ Molecular Weight ]:
1104.127

Related Compounds

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