6H-Purin-6-one,2-amino-1,9-dihydro-9-b-D-xylofuranosyl-

Modify Date: 2024-01-29 15:46:52

6H-Purin-6-one,2-amino-1,9-dihydro-9-b-D-xylofuranosyl- structure	Common Name	6H-Purin-6-one,2-amino-1,9-dihydro-9-b-D-xylofuranosyl-
	CAS Number	27462-39-1	Molecular Weight	283.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₃N₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 6H-Purin-6-one,2-amino-1,9-dihydro-9-b-D-xylofuranosyl-

9-(β-D-Xylofuranosyl)guanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	6H-Purin-6-one,2-amino-1,9-dihydro-9-b-D-xylofuranosyl

Description	9-(β-D-Xylofuranosyl)guanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Molecular Formula	C₁₀H₁₃N₅O₅
Molecular Weight	283.24
Exact Mass	283.09200
PSA	159.51000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8610000

CHEMICAL NAME :: Guanine, 9-(beta-D-xylofuranosyl)-

CAS REGISTRY NUMBER :: 27462-39-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H13-N5-O5

MOLECULAR WEIGHT :: 283.28

WISWESSER LINE NOTATION :: T56 BN DN FVM INJ HZ B1- BT5OTJ CQ DQ EQ -D,BETA,XYLO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,203,1986

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Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA