Pomalidomide-C5-Dovitinib

Modify Date: 2024-01-08 13:29:54

Pomalidomide-C5-Dovitinib Structure
Pomalidomide-C5-Dovitinib structure
 Common Name Pomalidomide-C5-Dovitinib
CAS Number 2732969-67-2 Molecular Weight 747.77
Density N/A Boiling Point N/A
Molecular Formula C39H38FN9O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pomalidomide-C5-Dovitinib


Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].

 Names

Name Pomalidomide-C5-Dovitinib

 Pomalidomide-C5-Dovitinib Biological Activity

Description Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].
Related Catalog
References

[1]. Cao S, et al. Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells. J Med Chem. 2021;64(22):16497-16511.

 Chemical & Physical Properties

Molecular Formula C39H38FN9O6
Molecular Weight 747.77
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