2732969-67-2

2732969-67-2 structure

Name: Pomalidomide-C5-Dovitinib
Chemical Name: Pomalidomide-C5-Dovitinib
CAS Number: 2732969-67-2
Molecular Formula: C₃₉H₃₈FN₉O₆
Molecular Weight: 747.77
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2022-04-12 23:47:45
Modify Date: 2024-01-08 13:29:54
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].

Name	Pomalidomide-C5-Dovitinib

Description	Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
References	[1]. Cao S, et al. Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells. J Med Chem. 2021;64(22):16497-16511.

Molecular Formula	C₃₉H₃₈FN₉O₆
Molecular Weight	747.77