Myristyl nicotinate

Modify Date: 2024-01-09 11:33:36

Myristyl nicotinate structure	Common Name	Myristyl nicotinate
	CAS Number	273203-62-6	Molecular Weight	319.48200
	Density	0.953g/cm3	Boiling Point	411.7ºC at 760 mmHg
	Molecular Formula	C₂₀H₃₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	202.8ºC

Use of Myristyl nicotinate

Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2].

Name	tetradecyl pyridine-3-carboxylate
Synonym	More Synonyms

Description	Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Myristyl nicotinate (Tetradecyl nicotinate) is used for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids[2].
References	[1]. Catz P, et al. Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829(1-2):123-35. [2]. Jacobson MK, et al. Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage. Exp Dermatol. 2007 Nov;16(11):927-35.

Density	0.953g/cm3
Boiling Point	411.7ºC at 760 mmHg
Molecular Formula	C₂₀H₃₃NO₂
Molecular Weight	319.48200
Flash Point	202.8ºC
Exact Mass	319.25100
PSA	39.19000
LogP	5.93950
Vapour Pressure	5.46E-07mmHg at 25°C
Index of Refraction	1.486