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273203-62-6

273203-62-6 structure
273203-62-6 structure
  • Name: Myristyl nicotinate
  • Chemical Name: tetradecyl pyridine-3-carboxylate
  • CAS Number: 273203-62-6
  • Molecular Formula: C20H33NO2
  • Molecular Weight: 319.48200
  • Catalog: Research Areas Cancer
  • Create Date: 2018-08-07 23:09:08
  • Modify Date: 2024-01-09 11:33:36
  • Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2].

Name tetradecyl pyridine-3-carboxylate
Synonyms myristyl nicotinic acid ester
8QWM6I035C
nicotinic acid tetradecyl ester
UNII-8QWM6I035C
n-tetradecyl nicotinic acid ester
MyristylNicotinate
Nicotinsaeure-tetradecylester
Tetradecyl nicotinate
Description Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2].
Related Catalog
In Vitro Myristyl nicotinate (Tetradecyl nicotinate) is used for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids[2].
References

[1]. Catz P, et al. Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829(1-2):123-35.

[2]. Jacobson MK, et al. Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage. Exp Dermatol. 2007 Nov;16(11):927-35.

Density 0.953g/cm3
Boiling Point 411.7ºC at 760 mmHg
Molecular Formula C20H33NO2
Molecular Weight 319.48200
Flash Point 202.8ºC
Exact Mass 319.25100
PSA 39.19000
LogP 5.93950
Vapour Pressure 5.46E-07mmHg at 25°C
Index of Refraction 1.486
Precursor  2

DownStream  0