ALK/EGFR-IN-1

Modify Date: 2024-01-04 00:56:46

ALK/EGFR-IN-1 structure	Common Name	ALK/EGFR-IN-1
	CAS Number	2730430-08-5	Molecular Weight	572.12
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₄ClN₇O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ALK/EGFR-IN-1

ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research[1].

Name	ALK/EGFR-IN-1

Description	ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
References	[1]. An B, et al. Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer. Bioorg Chem. 2023 Sep;138:106653.

Molecular Formula	C₂₇H₃₄ClN₇O₃S
Molecular Weight	572.12

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ALK/EGFR-IN-1

Use of ALK/EGFR-IN-1

Names

ALK/EGFR-IN-1 Biological Activity

Chemical & Physical Properties