2730430-08-5

2730430-08-5 structure

Name: ALK/EGFR-IN-1
Chemical Name: ALK/EGFR-IN-1
CAS Number: 2730430-08-5
Molecular Formula: C₂₇H₃₄ClN₇O₃S
Molecular Weight: 572.12
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-12-12 15:07:49
Modify Date: 2026-09-13 18:41:23
ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research[1].

Name	ALK/EGFR-IN-1
Synonyms	2-Propenamide, N-[5-[[5-chloro-4-[[2-(ethylsulfinyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]

Description	ALK/EGFR-IN-1 (Compound 8l) is an ALK/EGFR dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC50 of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
References	[1]. An B, et al. Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer. Bioorg Chem. 2023 Sep;138:106653.

Molecular Formula	C₂₇H₃₄ClN₇O₃S
Molecular Weight	572.12