Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

Modify Date: 2025-09-01 16:59:22

Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- Structure
Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- structure
 Common Name Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
CAS Number 2730-82-7 Molecular Weight 427.44700
Density 1.29g/cm3 Boiling Point 786.9ºC at 760mmHg
Molecular Formula C23H25NO7 Melting Point N/A
MSDS N/A Flash Point 429.7ºC

 Use of Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-


4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1].

 Names

Name N-(4-formyl-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
Synonym More Synonyms

  Biological Activity

Description 4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1].
Related Catalog
In Vitro 4-Formylcolchicine (compound 7) (0-5 µM; 24 h) shows antiproliferative activity with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. Cell Viability Assay[1] Cell Line: A549, HT-29, HCT116 cells Concentration: 0-5 µM Incubation Time: 24 h Result: Inhibited cell growth with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively.
References

[1]. Yasobu N, et al. Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. ACS Med Chem Lett. 2011 Mar 4;2(5):348-52.

 Chemical & Physical Properties

Density 1.29g/cm3
Boiling Point 786.9ºC at 760mmHg
Molecular Formula C23H25NO7
Molecular Weight 427.44700
Flash Point 429.7ºC
Exact Mass 427.16300
PSA 100.16000
LogP 3.07500
Vapour Pressure 9.93E-25mmHg at 25°C
Index of Refraction 1.589

 Synthetic Route

Dichloromethyl methyl ether structure

Dichloromethyl ...

CAS#:4885-02-3

Colchicine structure

Colchicine

CAS#:64-86-8

~99%

Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- Structure

Acetamide,N-[(7...

CAS#:2730-82-7

Literature: Yasobu, Naoko; Kitajima, Mariko; Kogure, Noriyuki; Shishido, Yoshiyuki; Matsuzaki, Takeshi; Nagaoka, Masato; Takayama, Hiromitsu ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 5 p. 348 - 352

 Synonyms

1-Formylcolchicin
4-Formylcolchicine
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Chemsrc provides CAS#:2730-82-7 MSDS, density, melting point, boiling point, structure, etc. Its name is Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]->> amp version: Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

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