N-Desmethyl dosimertinib-d5

Modify Date: 2025-08-25 18:56:08

N-Desmethyl dosimertinib-d5 structure	Common Name	N-Desmethyl dosimertinib-d5
	CAS Number	2719691-00-4	Molecular Weight	490.61
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₆D₅N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N-Desmethyl dosimertinib-d5

N-Desmethyl dosimertinib-d5 is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].

Name	N-Desmethyl dosimertinib-d5

Description	N-Desmethyl dosimertinib-d5 is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64(2):925-937.

Molecular Formula	C₂₇H₂₆D₅N₇O₂
Molecular Weight	490.61

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N-Desmethyl dosimertinib-d5

Use of N-Desmethyl dosimertinib-d5

Names

N-Desmethyl dosimertinib-d5 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.