2719691-00-4

2719691-00-4 structure

Name: N-Desmethyl dosimertinib-d5
Chemical Name: N-Desmethyl dosimertinib-d5
CAS Number: 2719691-00-4
Molecular Formula: C₂₇H₂₆D₅N₇O₂
Molecular Weight: 490.61
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-03-31 15:31:12
Modify Date: 2024-04-06 18:03:16
N-Desmethyl dosimertinib-d5 is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].

Name	N-Desmethyl dosimertinib-d5

Description	N-Desmethyl dosimertinib-d5 is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64(2):925-937.

Molecular Formula	C₂₇H₂₆D₅N₇O₂
Molecular Weight	490.61