CHD1Li 6.11

Modify Date: 2025-08-25 08:43:03

CHD1Li 6.11 Structure
CHD1Li 6.11 structure
Common Name CHD1Li 6.11
CAS Number 2716890-91-2 Molecular Weight 472.40
Density N/A Boiling Point N/A
Molecular Formula C21H22BrN5OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CHD1Li 6.11


CHD1Li 6.11 is a potent oncogenic CHD1L inhibitor (IC50=3.3 µM for cat-CHD1L recombinant protein). CHD1Li 6.11 is an orally bioavailable antitumor agent, significantly reducing the tumor volume of CRC xenografts generated from isolated quasi mesenchymal cells (M-phenotype), which possess enhanced tumorigenic properties[1].

 Names

Name CHD1Li 6.11

 CHD1Li 6.11 Biological Activity

Description CHD1Li 6.11 is a potent oncogenic CHD1L inhibitor (IC50=3.3 µM for cat-CHD1L recombinant protein). CHD1Li 6.11 is an orally bioavailable antitumor agent, significantly reducing the tumor volume of CRC xenografts generated from isolated quasi mesenchymal cells (M-phenotype), which possess enhanced tumorigenic properties[1].
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References

[1]. Prigaro BJ, et al. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022;65(5):3943-3961.

 Chemical & Physical Properties

Molecular Formula C21H22BrN5OS
Molecular Weight 472.40
InChIKey ACDZBXZERLBYOW-UHFFFAOYSA-N
SMILES Cc1cc(Nc2ccc(NC(=O)Cc3cc(Br)cs3)cc2)nc(N2CCCC2)n1
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