SD-06

Modify Date: 2024-01-14 15:48:50

SD-06 structure	Common Name	SD-06
	CAS Number	271576-80-8	Molecular Weight	397.858
	Density	1.4±0.1 g/cm3	Boiling Point	652.6±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀ClN₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	348.5±31.5 °C

Use of SD-06

SD 0006 (SD-06) is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).

Name	1-[4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone
Synonym	More Synonyms

Description	SD 0006 (SD-06) is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
Target	IC50: 170 nM (p38MAPK).

Density	1.4±0.1 g/cm3
Boiling Point	652.6±55.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀ClN₅O₂
Molecular Weight	397.858
Flash Point	348.5±31.5 °C
Exact Mass	397.130554
PSA	95.00000
LogP	1.50
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.638

4-[3-(4-chlorop...

CAS#:271576-76-2

Butyl glycolate

CAS#:7397-62-8

~80%

SD-06

CAS#:271576-80-8

Literature: Allen, Kimberley C.; Anderson, Dennis K.; Baldus, John E.; Boehlow, Todd; Clark, Jerry D.; Dukesherer, Daniel R.; Edney, Albert D.; Fevig, Tom; Kundra, Sastry; Lawson, Jon P.; Lau, Patrick H.; McDermott, Lisa L.; Mao, Michael K.; Moe, Jodi L.; Mudipalli, Partha; Naing, Win; Selness, Shaun R.; Seymour, Christine B.; Schilke, Tobin C.; Viswanath, Shekhar; Walker, John K.; Yalamanchili, Gopichand Patent: US2003/225108 A1, 2003 ; Location in patent: Page 37-39 ;

4-[3-(4-chlorop...

CAS#:271576-76-2

Hydroxypyruvic acid

CAS#:1113-60-6

SD-06

CAS#:271576-80-8

Literature: Walker, John K.; Selness, Shaun R.; Devraj, Rajesh V.; Hepperle, Michael E.; Naing, Win; Shieh, Huey; Kurambail, Ravi; Yang, Syaulan; Flynn, Daniel L.; Benson, Alan G.; Messing, Dean M.; Dice, Tom; Kim, Tina; Lindmark; Monahan, Joseph B.; Portanova, Joseph Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 8 p. 2634 - 2638

Precursor 2
CAS#:7397-62-8 Butyl glycolate CAS#:1113-60-6 Hydroxypyruvic acid
DownStream 0

SD06

2-{4-[5-(4-Chlorophenyl)-4-Pyrimidin-4-Yl-1h-Pyrazol-3-Yl]piperidin-1-Yl}-2-Oxoethanol

1-{4-[5-(4-Chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl}-2-hydroxyethanone

SD-06

3hl7

N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole

Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-

2-{4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl}-2-oxoethanol

1-{4-[5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl]piperidin-1-yl}-2-hydroxyethanone

DC Chemicals Limited
China
Product Name: SD-06
Price: $650.0/100mg $1200.0/250mg $2500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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SD-06 suppliers

Price: $508/10mM*1mLinDMSO

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SD-06

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SD-06 Biological Activity

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Precursor & DownStream

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