Timolol

Modify Date: 2025-08-21 17:38:36

Timolol structure	Common Name	Timolol
	CAS Number	26839-75-8	Molecular Weight	316.42000
	Density	1.224 g/cm3	Boiling Point	487.2ºC at 760 mmHg
	Molecular Formula	C₁₃H₂₄N₄O₃S	Melting Point	71.5 - 72.5ºC
	MSDS	N/A	Flash Point	248.5ºC

Use of Timolol

Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].

Name	(S)-timolol (anhydrous)
Synonym	More Synonyms

Description	Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vitro	Timolol can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].
In Vivo	Timolol has a cardioprotective effect via inhibition of ERS response in diabetic rats[3]. Animal Model: Experimental diabetes model: 3-month old male Wistar rats[3]. Dosage: 5 mg/kg Administration: Timolol (5 mg/kg daily for 12-week) Result: Showed cardioprotective effect.
References	[1]. James Barnes; Majid Moshirfar. Timolol. [2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152. [3]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr

Density	1.224 g/cm3
Boiling Point	487.2ºC at 760 mmHg
Melting Point	71.5 - 72.5ºC
Molecular Formula	C₁₃H₂₄N₄O₃S
Molecular Weight	316.42000
Flash Point	248.5ºC
Exact Mass	316.15700
PSA	107.98000
LogP	0.95840
Vapour Pressure	2.62E-10mmHg at 25°C
Index of Refraction	1.548

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DownStream 1
CAS#:26921-17-5 (S)-timolol maleate