Thalidomide-5-O-CH2-COO(t-Bu)

Modify Date: 2024-02-26 13:03:56

Thalidomide-5-O-CH2-COO(t-Bu) structure	Common Name	Thalidomide-5-O-CH2-COO(t-Bu)
	CAS Number	2682112-10-1	Molecular Weight	388.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₀N₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-5-O-CH2-COO(t-Bu)

Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

Name	Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]oxy]-, 1,1-dimethylethyl ester
Synonym	More Synonyms

Description	Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Molecular Formula	C₁₉H₂₀N₂O₇
Molecular Weight	388.37

acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1h-isoindol-5-yl]oxy]-, 1,1-dime

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Thalidomide-5-O-CH2-COO(t-Bu)
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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Thalidomide-5-O-CH2-COO(t-Bu)

Use of Thalidomide-5-O-CH2-COO(t-Bu)

Names

Thalidomide-5-O-CH2-COO(t-Bu) Biological Activity

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