Thalidomide-5-O-CH2-COO(t-Bu)
Modify Date: 2024-02-26 13:03:56
Thalidomide-5-O-CH2-COO(t-Bu) structure
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Common Name | Thalidomide-5-O-CH2-COO(t-Bu) | ||
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| CAS Number | 2682112-10-1 | Molecular Weight | 388.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H20N2O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Thalidomide-5-O-CH2-COO(t-Bu)Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules. |
| Name | Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]oxy]-, 1,1-dimethylethyl ester |
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| Synonym | More Synonyms |
| Description | Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules. |
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| Related Catalog |
| Molecular Formula | C19H20N2O7 |
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| Molecular Weight | 388.37 |
| acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1h-isoindol-5-yl]oxy]-, 1,1-dime |