Thalidomide-5-O-CH2-COO(t-Bu)
Names
[ CAS No. ]:
2682112-10-1
[ Name ]:
Thalidomide-5-O-CH2-COO(t-Bu)
[Synonym ]:
acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1h-isoindol-5-yl]oxy]-, 1,1-dime
Biological Activity
[Description]:
Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
[Related Catalog]:
Chemical & Physical Properties
[ Molecular Formula ]:
C19H20N2O7
[ Molecular Weight ]:
388.37