NLRP3-IN-25

Modify Date: 2024-03-08 11:18:21

NLRP3-IN-25 structure	Common Name	NLRP3-IN-25
	CAS Number	2660230-90-8	Molecular Weight	448.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₉F₃N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NLRP3-IN-25

NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1].

Name	NLRP3-IN-25

Description	NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
References	[1]. Ohba Y et al. Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide[J]. ACS Medicinal Chemistry Letters, 2023.

Molecular Formula	C₁₇H₁₉F₃N₄O₅S
Molecular Weight	448.42

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NLRP3-IN-25

Use of NLRP3-IN-25

Names

NLRP3-IN-25 Biological Activity

Chemical & Physical Properties