TLR7/8 agonist 8

Modify Date: 2025-08-25 11:43:36

TLR7/8 agonist 8 structure	Common Name	TLR7/8 agonist 8
	CAS Number	2649170-16-9	Molecular Weight	418.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₀N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TLR7/8 agonist 8

TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1].

Name	TLR7/8 agonist 8

Description	TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer
Target	TLR7:27 nM (EC50) TLR8:12 nM (EC50)
References	[1]. Wang Z, et, al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64(11):7507-7532.

Molecular Formula	C₂₄H₃₀N₆O
Molecular Weight	418.53
InChIKey	MJIGXQDERFISLK-UHFFFAOYSA-N
SMILES	CCCCNc1nc(N)nc2ccc(Cc3ccc(CN4CC5(COC5)C4)cc3)nc12

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

TLR7/8 agonist 8

Use of TLR7/8 agonist 8

Names

TLR7/8 agonist 8 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.