TLR7/8 agonist 8

Names

[ CAS No. ]:
2649170-16-9

[ Name ]:
TLR7/8 agonist 8

Biological Activity

[Description]:

TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Cancer

[Target]

TLR7:27 nM (EC50)

TLR8:12 nM (EC50)


[References]

[1]. Wang Z, et, al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64(11):7507-7532.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H30N6O

[ Molecular Weight ]:
418.53

Related Compounds

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