Iboxamycin

Modify Date: 2024-01-02 11:34:41

Iboxamycin Structure
Iboxamycin structure
Common Name Iboxamycin
CAS Number 2640000-92-4 Molecular Weight 495.07
Density N/A Boiling Point N/A
Molecular Formula C22H39ClN2O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Iboxamycin


Iboxamycin is a potent antibiotic candidate bearing a fused bicyclic amino acid residue. Iboxamycin is orally bioavailable, safe and effective in treating both Gram-positive and Gram-negative bacterial infections in mice[1][2].

 Names

Name Iboxamycin

 Iboxamycin Biological Activity

Description Iboxamycin is a potent antibiotic candidate bearing a fused bicyclic amino acid residue. Iboxamycin is orally bioavailable, safe and effective in treating both Gram-positive and Gram-negative bacterial infections in mice[1][2].
Related Catalog
In Vitro Iboxamycin is effective against ESKAPE pathogens including strains expressing Erm and Cfr ribosomal RNA methyltransferase enzymes, products of genes that confer resistance to all clinically relevant antibiotics targeting the large ribosomal subunit, namely macrolides, lincosamides, phenicols, oxazolidinones, pleuromutilins and streptogramins[2].
References

[1]. Mason JD, et al. Practical Gram-Scale Synthesis of Iboxamycin, a Potent Antibiotic Candidate. J Am Chem Soc. 2021;143(29):11019-11025.

[2]. Mitcheltree MJ, et al. A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature. 2021;599(7885):507-512.

 Chemical & Physical Properties

Molecular Formula C22H39ClN2O6S
Molecular Weight 495.07
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