Reticulol
Modify Date: 2024-01-13 19:24:04
Reticulol structure
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Common Name | Reticulol | ||
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| CAS Number | 26246-41-3 | Molecular Weight | 222.19 | |
| Density | 1.424g/cm3 | Boiling Point | 473.2ºC at 760mmHg | |
| Molecular Formula | C11H10O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 192.2ºC | |
Use of ReticulolReticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2]. |
| Name | 6,8-dihydroxy-7-methoxy-3-methylisochromen-1-one |
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| Synonym | More Synonyms |
| Description | Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2]. |
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| Related Catalog | |
| In Vitro | Reticulol (25-200 μM) 对人肺肿瘤细胞系 A427 和小鼠黑色素瘤细胞系 B16F10 显示出有效的细胞毒性[1]。 |
| In Vivo | Reticulol (10 mg/kg，50 mg/kg；静脉注射；肿瘤植入后第 3 天和第 5 天) 抑制 B16F10 黑色素瘤小鼠的肿瘤生长，并显示肺转移阻断作用[1]。 Animal Model: Pathogen-free female C57BL/6J mice[1] Dosage: 10 mg/kg, 50 mg/kg Administration: IV via the tail vein; day 3 and day 5 after tumor implanted Result: Inhibited tumor growth. |
| References |
| Density | 1.424g/cm3 |
|---|---|
| Boiling Point | 473.2ºC at 760mmHg |
| Molecular Formula | C11H10O5 |
| Molecular Weight | 222.19 |
| Flash Point | 192.2ºC |
| Exact Mass | 222.05300 |
| PSA | 79.90000 |
| LogP | 1.52120 |
| Vapour Pressure | 1.4E-09mmHg at 25°C |
| Index of Refraction | 1.621 |
| HS Code | 2932999099 |
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| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 6,8-dihydroxy-7-methoxy-3-methyl-isochromen-1-one |
| Reticulol |
| 6,8-Dihydroxy-7-methoxy-3-methylisocumarin |