Reticulol

Names

[ Name ]:
Reticulol

[Synonym ]:
6,8-dihydroxy-7-methoxy-3-methyl-isochromen-1-one
Reticulol
6,8-Dihydroxy-7-methoxy-3-methylisocumarin

Biological Activity

[Description]:

Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[In Vitro]

Reticulol (25-200 μM) 对人肺肿瘤细胞系 A427 和小鼠黑色素瘤细胞系 B16F10 显示出有效的细胞毒性[1]。

[In Vivo]

Reticulol (10 mg/kg，50 mg/kg；静脉注射；肿瘤植入后第 3 天和第 5 天) 抑制 B16F10 黑色素瘤小鼠的肿瘤生长，并显示肺转移阻断作用[1]。 Animal Model: Pathogen-free female C57BL/6J mice[1] Dosage: 10 mg/kg, 50 mg/kg Administration: IV via the tail vein; day 3 and day 5 after tumor implanted Result: Inhibited tumor growth.

[References]

[1]. Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo). 1975 Jul;28(7):558-60.

[2]. Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49(3):146-53.

Chemical & Physical Properties

[ Density]:
1.424g/cm3

[ Boiling Point ]:
473.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₀O₅

[ Molecular Weight ]:
222.19

[ Flash Point ]:
192.2ºC

[ Exact Mass ]:
222.05300

[ PSA ]:
79.90000

[ LogP ]:
1.52120

[ Vapour Pressure ]:
1.4E-09mmHg at 25°C

[ Index of Refraction ]:
1.621

Safety Information

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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