(1S,2S)-ML-SI3
Modify Date: 2025-08-25 13:18:31
(1S,2S)-ML-SI3 structure
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Common Name | (1S,2S)-ML-SI3 | ||
|---|---|---|---|---|
| CAS Number | 2563870-87-9 | Molecular Weight | 429.58 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H31N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (1S,2S)-ML-SI3(1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a TRPML inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC50=5.9 μM), but an activator on TRPML 2 and 3[1]. |
| Name | (1S,2S)-ML-SI3 |
|---|
| Description | (1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a TRPML inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC50=5.9 μM), but an activator on TRPML 2 and 3[1]. |
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| Related Catalog | |
| Target |
IC50: 1.6 μM (TRPML1), 2.3 μM (TRPML2), 12.5 (TRPML3) for the (-)-isome of (1S,2S)-ML-SI3; 5.9 μM (TRPML1) for the (+)-enantiomer[1] |
| References |
| Molecular Formula | C23H31N3O3S |
|---|---|
| Molecular Weight | 429.58 |
| InChIKey | OVTXOMMQHRIKGL-SFTDATJTSA-N |
| SMILES | COc1ccccc1N1CCN(C2CCCCC2NS(=O)(=O)c2ccccc2)CC1 |