2563870-87-9
2563870-87-9 structure
- Name: (1S,2S)-ML-SI3
- Chemical Name: (1S,2S)-ML-SI3
- CAS Number: 2563870-87-9
- Molecular Formula: C23H31N3O3S
- Molecular Weight: 429.58
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2023-10-03 21:09:45
- Modify Date: 2024-01-19 16:32:49
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(1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a TRPML inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC50=5.9 μM), but an activator on TRPML 2 and 3[1].
| Name | (1S,2S)-ML-SI3 |
|---|
| Description | (1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a TRPML inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC50=5.9 μM), but an activator on TRPML 2 and 3[1]. |
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| Related Catalog | |
| Target |
IC50: 1.6 μM (TRPML1), 2.3 μM (TRPML2), 12.5 (TRPML3) for the (-)-isome of (1S,2S)-ML-SI3; 5.9 μM (TRPML1) for the (+)-enantiomer[1] |
| References |
| Molecular Formula | C23H31N3O3S |
|---|---|
| Molecular Weight | 429.58 |