2-MPPA

Modify Date: 2024-01-11 12:46:43

Use of 2-MPPA

2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM[1][2].

Name	2-(3-sulfanylpropyl)pentanedioic acid
Synonym	More Synonyms

Description	2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carboxypeptidase Research Areas >> Neurological Disease
Target	IC50: 90 nM (GCP II)[2]
In Vivo	2-MPPA (10, 30 or 100 mg/kg) significantly attenuates Dizocilpine (HY-15084B) (0.1 mg/kg)-induced prepulse inhibition (PPI) deficits in mice, in a dose dependent manner. The efficacy of 2-MPPA on dizocilpine-induced PPI deficits is significantly antagonized by pretreatment with the selective group II metabotropic glutamate receptor (mGluR) antagonist LY341495 (HY-70059) (1.0 mg/kg)[1]. 2-MPPA (30 mg/kg) significantly prevents the deficit in SNCV induced by both 5 and 25 mg/kg taxol by 96.3 ± 4.4% and 98.3± 11.6% respectively[2]. 2-MPPA (10 mg/kg) inhibits tumor growth in the high expressor PSMA model CWR22RS by 70%[2].
References	[1]. Takatsu Y, et al. Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice. Brain Res. 2011 Jan 31;1371:82-6. [2]. She Y, et al. 2-MPPA, a selective inhibitor of PSMA, delays prostate cancer growth and attenuates taxol-induced neuropathy in mice. Journal of Clinical Oncology, 2005, 23(16_suppl): 8054-8054.

2-(3-tritylsulf...

CAS#:254737-43-4

~72%

2-MPPA

CAS#:254737-29-6

Precursor 1
CAS#:254737-43-4 2-(3-tritylsulf...
DownStream 0

2-(3-mercaptopropyl)pentanedioic acid

2-MPPA

Pentanedioic acid,2-(3-mercaptopropyl)