4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one

Modify Date: 2024-01-02 12:54:04

4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one structure	Common Name	4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
	CAS Number	25392-41-0	Molecular Weight	210.614
	Density	1.4±0.1 g/cm3	Boiling Point	409.6±45.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₇ClO₃	Melting Point	180-183ºC
	MSDS	N/A	Flash Point	201.5±28.7 °C

Use of 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one

4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].

Name	4-(chloromethyl)-7-hydroxychromen-2-one
Synonym	More Synonyms

Description	4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26(10):773-783. [2]. Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19):5892-5896.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26(10):773-783.

[2]. Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19):5892-5896.

Density	1.4±0.1 g/cm3
Boiling Point	409.6±45.0 °C at 760 mmHg
Melting Point	180-183ºC
Molecular Formula	C₁₀H₇ClO₃
Molecular Weight	210.614
Flash Point	201.5±28.7 °C
Exact Mass	210.008377
PSA	50.44000
LogP	2.38
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.619
Storage condition	2-8℃

Hazard Codes	Xi
HS Code	2932209090

Ethyl 2-Chloroa...

CAS#:638-07-3

Resorcine

CAS#:108-46-3

~94%

4-(Chloromethyl...

CAS#:25392-41-0

Literature: Reddy, Y. Thirupathi; Sonar, Vijayakumar N.; Crooks, Peter A.; Dasari, Pavan K.; Reddy, P. Narsimha; Rajitha Synthetic Communications, 2008 , vol. 38, # 13 p. 2082 - 2088

Pyrrole-1-propi...

CAS#:32807-28-6

Resorcine

CAS#:108-46-3

~85%

4-(Chloromethyl...

CAS#:25392-41-0

Literature: Sharghi, Hashem; Jokar, Mahboubeh Heterocycles, 2007 , vol. 71, # 12 p. 2721 - 2733

Precursor 3
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DownStream 6
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