Crebanine

Modify Date: 2024-01-02 18:50:52

Crebanine structure	Common Name	Crebanine
	CAS Number	25127-29-1	Molecular Weight	339.385
	Density	1.3±0.1 g/cm3	Boiling Point	488.2±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	145.4±25.9 °C

Use of Crebanine

Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect[1][2].

Name	Crebanin
Synonym	More Synonyms

Description	Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> PI3K/Akt/mTOR >> Akt Research Areas >> Inflammation/Immunology
References	[1]. Wongsirisin P, et al. Induction of G1 arrest and apoptosis in human cancer cells by crebanine, an alkaloid from Stephania venosa. Chem Pharm Bull (Tokyo). 2012;60(10):1283-9. [2]. Intayoung P, et al. Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW264.7 Macrophages. Biol Pharm Bull. 2016;39(1):54-61.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

Research Areas >> Inflammation/Immunology

References

[1]. Wongsirisin P, et al. Induction of G1 arrest and apoptosis in human cancer cells by crebanine, an alkaloid from Stephania venosa. Chem Pharm Bull (Tokyo). 2012;60(10):1283-9.

[2]. Intayoung P, et al. Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW264.7 Macrophages. Biol Pharm Bull. 2016;39(1):54-61.

Density	1.3±0.1 g/cm3
Boiling Point	488.2±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.385
Flash Point	145.4±25.9 °C
Exact Mass	339.147064
PSA	40.16000
LogP	3.98
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.616
Storage condition	-20℃