BR102910
Modify Date: 2024-01-13 15:11:05
BR102910 structure
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Common Name | BR102910 | ||
|---|---|---|---|---|
| CAS Number | 2505339-54-6 | Molecular Weight | 459.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H14Cl2F2N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BR102910BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2 |
| Name | BR102910 |
|---|
| Description | BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2 |
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| Related Catalog | |
| Target |
IC50: 2 nM (FAP), 49.0 μM (PREP), >100 μM (DPP-4)[1] |
| In Vivo | BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner[1]. Animal Model: C57BL/6J mice (n = 5 per group)[1] Dosage: 0, 10 and 30 mg/kg Administration: Orally, once Result: Showed significant FAP inhibition in a dose dependent manner. |
| References |
| Molecular Formula | C18H14Cl2F2N4O2S |
|---|---|
| Molecular Weight | 459.30 |
| InChIKey | JTSUDVSZJDOOJG-NSHDSACASA-N |
| SMILES | N#CC1CC(F)(F)CN1C(=O)CNC(=O)c1csc(Cc2ccc(Cl)c(Cl)c2)n1 |