N-acetyl-2,3-didehydro-2-deoxyneuraminic acid structure
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Common Name | N-acetyl-2,3-didehydro-2-deoxyneuraminic acid | ||
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CAS Number | 24967-27-9 | Molecular Weight | 291.25500 | |
Density | 1.58g/cm3 | Boiling Point | 773.4ºC at 760 mmHg | |
Molecular Formula | C11H17NO8 | Melting Point | 227-228ºC | |
MSDS | Chinese USA | Flash Point | 421.6ºC |
Use of N-acetyl-2,3-didehydro-2-deoxyneuraminic acidN-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2]. |
Name | n-acetylneuraminic acid, 2,3-dehydro-2-deoxy-, sodium salt |
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Synonym | More Synonyms |
Description | N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2]. |
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Related Catalog | |
In Vitro | N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) signifcantly inhibits sialidase activity in INS-1D cells[4]. |
In Vivo | N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10 mg/kg; i.p.; daily) attenuates pulmonary fibrosis in a mouse model[3]. Animal Model: Mice (Mouse model of pulmonary fibrosis)[3] Dosage: 10 mg/kg Administration: I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21) Result: Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis. |
References |
Density | 1.58g/cm3 |
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Boiling Point | 773.4ºC at 760 mmHg |
Melting Point | 227-228ºC |
Molecular Formula | C11H17NO8 |
Molecular Weight | 291.25500 |
Flash Point | 421.6ºC |
Exact Mass | 291.09500 |
PSA | 156.55000 |
Vapour Pressure | 1.27E-27mmHg at 25°C |
Index of Refraction | 1.612 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Safety Phrases | 22-24/25 |
RIDADR | NONH for all modes of transport |
Chemistry, metabolism, and biological functions of sialic acids.
Adv. Carbohydr. Chem. Biochem. 40 , 131, (1982)
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Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.
J. Med. Chem. 56(7) , 2948-58, (2013) In the past two decades, human neuraminidases (human sialidases, hNEUs) have been found to be involved in numerous pathways in biology. The development of selective and potent inhibitors of these enzy... |
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Elastin-derived peptides are new regulators of insulin resistance development in mice.
Diabetes 62(11) , 3807-16, (2013) Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also been demonstrated to play an... |
5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galactonon-2-enonic acid |
2,3,4-TRIMETHYL-3-PENTANOL |
5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enoic acid |
N-acetyl-2,3-didehydro-2-deoxyneuraminic acid |
1,3-DEHYDRO-2-DEOXY-N-ACETYLNEURAMINIC ACID |
2,3-DEHYDRO-2-DEOXY-N-ACETYLNEURAMINIC ACID |
2,3-Dehydro-2-deoxy-N-acetylneuraminic AcidDANA |
MFCD00057470 |
N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid |
2,3-didehydro-2-deoxy-N-acetylneuraminic acid |
2-deoxy-2,3-dehydro-n-acetylneuraminicacid |
EINECS 246-550-7 |