ATX inhibitor 15

Modify Date: 2025-08-26 18:10:23

ATX inhibitor 15 Structure
ATX inhibitor 15 structure
Common Name ATX inhibitor 15
CAS Number 2484811-52-9 Molecular Weight 380.36
Density N/A Boiling Point N/A
Molecular Formula C19H19F3N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ATX inhibitor 15


ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1].

 Names

Name ATX inhibitor 15

 ATX inhibitor 15 Biological Activity

Description ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1].
Related Catalog
Target

Autotaxin:2.17 nM (IC50)

References

[1]. Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951.

 Chemical & Physical Properties

Molecular Formula C19H19F3N2O3
Molecular Weight 380.36
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.