Sulfopin
Modify Date: 2025-08-26 19:17:12
Sulfopin structure
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Common Name | Sulfopin | ||
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| CAS Number | 2451481-08-4 | Molecular Weight | 281.80 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H20ClNO3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SulfopinSulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors[1]. |
| Name | Sulfopin |
|---|
| Description | Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors[1]. |
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| Related Catalog | |
| In Vitro | MDA-MB-468 cells show the most pronounced sensitivity to Sulfopin (1, 2.5 μM; 4-8 days)[1]. Sulfopin (2 μM, HEK293 cells; 48 hours) downregulates Myc transcription[1]. Sulfopin (1, 2.5 μM; PATU-8988T cells; 4 days) shows a small but significant reduction in the number of synthesis (S)-phase cells and a corresponding increase of growth 1 (G1)-phase cells[1]. Cell Proliferation Assay[1] Cell Line: Kuramochi, MDA-MB-468, NGP, NBL-S, MDA-MB-468 cells Concentration: 1, 2.5 μM Incubation Time: 4,6, 8 days Result: Showed variation in antiproliferative effects across cancer cell lines Kuramochi, MDA-MB-468, NGP and NBL-S, with the most pronounced sensitivity observed in MDA-MB-468 cells. |
| In Vivo | Sulfopin (40 mg/kg; p.o.; QD/BID for 7 days) regresses neuroblastoma in mice[1]. Sulfopin (20-40 mg/kg; i.p.; daily for 27 days) inhibits pancreatic cancer progression in mice[1]. Sulfopin (25-100 μM) blocks neuroblastoma in zebrafish[1]. Animal Model: Transgenic Th-MYCN mice[1] Dosage: 40 mg/kg Administration: Once a day (QD) or twice a day (BID) for 7 days Result: Sulfopin-treated QD mice showed a significant average increase in survival of 10 days, while Sulfopin-treated BID mice showed an even more pronounced average increase of 28 days. |
| References |
| Molecular Formula | C11H20ClNO3S |
|---|---|
| Molecular Weight | 281.80 |
| Storage condition | -20°C |