Malachite green oxalate

Modify Date: 2024-01-02 17:52:21

Malachite green oxalate structure	Common Name	Malachite green oxalate
	CAS Number	2437-29-8	Molecular Weight	454.946
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₂H₅₄N₄O₁₂	Melting Point	164°C (dec.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS05, GHS06, GHS08, GHS09	Signal Word	Danger

Use of Malachite green oxalate

Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].

Name	Basic Green 4
Synonym	More Synonyms

Description	Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IKBKE[3]
References	[1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13. [2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91. [3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.

Melting Point	164°C (dec.)
Molecular Formula	C₅₂H₅₄N₄O₁₂
Molecular Weight	454.946
Exact Mass	454.165924
PSA	241.96000
LogP	3.58460
Storage condition	Store at RT.
Water Solubility	60 g/L (20 ºC)

Malachite green oxalate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BQ1190000

CAS REGISTRY NUMBER :: 2437-29-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C46-H50-N4.C2-H2-O4.2C2-H-O4

MOLECULAR WEIGHT :: 927.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 40 ug/plate

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 56,43,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2442 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 112 (estimated) No. of Female Employees: 41 (estimated)

Symbol	GHS05, GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H301-H318-H361d-H410
Precautionary Statements	Missing Phrase - N15.00950417-P280-P305 + P351 + P338 + P310
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn;N
Risk Phrases	R22;R41;R50/53;R63
Safety Phrases	S26-S39-S45-S61-S60-S46-S36/37-S2-S36/37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	BQ1190000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	32041300

HS Code	32041300

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Streptavidin binding bifunctional aptamers and their interaction with low molecular weight ligands.

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This paper describes the measurement of the binding affinities of two bifunctional RNA aptamers to their respective ligands. The aptamers comprise either a theophylline or malachite green binding sequ...

EINECS 219-441-7

4-{[4-(Dimethylamino)phenyl](phenyl)methylene}-N,N-dimethyl-2,5-cyclohexadien-1-iminium chloride - ethanedioic acid (1:1:1)

4,4'-bis-dimethylamino-tritylium,oxalate

Malachite Green,Oxalate

N-(4-{[4-(Dimethylamino)phenyl](phenyl)methylene}cyclohexa-2,5-dien-1-ylidene)-N-methylmethanaminium chloride ethanedioic acid (1:1:1)

Malachite Green oxalate,high purity biological stain

Basisgreen4

Malachite Green oxalate,certified

OXALATE

N-(4-{[4-(dimethylamino)phenyl](phenyl)methylidene}cyclohexa-2,5-dien-1-ylidene)-N-methylmethanaminium chloride - ethanedioic acid (1:1:1)

MFCD00011766

Malachite green oxalate

LIGHT GREEN N

SOLID GREEN O

malachite green,oxalate salt

Ethanedioate

BASIC GREEN

4,4'-Bis-dimethylamino-tritylium,Oxalat

Carboxyformate

Malachite green

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Malachite green oxalate
Price: ￥108.0/100g
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Malachite green oxalate
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Basic green 4
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Basic Green 4
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Basic Green 4
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥550/10 mM * 1 mL in DMSO

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Malachite green oxalate

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