Sivopixant

Modify Date: 2024-01-03 11:51:46

Sivopixant structure	Common Name	Sivopixant
	CAS Number	2414285-40-6	Molecular Weight	507.93
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₂ClN₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Sivopixant

Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1].

Name	Sivopixant

Description	Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Research Areas >> Neurological Disease
In Vivo	Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED50=0.4 mg/kg)[1].
References	[1]. Kai H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists [published online ahead of print, 2021 Sep 26]. Bioorg Med Chem Lett. 2021;52:128384.

Molecular Formula	C₂₅H₂₂ClN₅O₅
Molecular Weight	507.93

DC Chemicals Limited
China
Product Name: Sivopixant
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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