EGFR-IN-89

Modify Date: 2025-08-24 13:12:00

EGFR-IN-89 structure	Common Name	EGFR-IN-89
	CAS Number	2413029-40-8	Molecular Weight	538.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₁FN₈O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EGFR-IN-89

EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type[1].

Name	EGFR-IN-89

Description	EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR19del/TM/CS:10.1 nM (IC50)
References	[1]. Jiyoung Jeon, et al. Design and synthesis of 4th generation EGFR inhibitors against human triple (Del19/T790M/C797S) mutation. Eur J Med Chem. 2023 Sep 27:261:115840.

Molecular Formula	C₂₆H₃₁FN₈O₂S
Molecular Weight	538.64
InChIKey	IGBZJJZEZHTAIC-UHFFFAOYSA-N
SMILES	CCN1CCN(c2ccc(Nc3nc(Nc4ccccc4N(C)S(C)(=O)=O)c4cc[nH]c4n3)cc2F)CC1

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