EGFR-IN-89

Names

[ CAS No. ]:
2413029-40-8

[ Name ]:
EGFR-IN-89

Biological Activity

[Description]:

EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR19del/TM/CS:10.1 nM (IC50)


[References]

[1]. Jiyoung Jeon, et al. Design and synthesis of 4th generation EGFR inhibitors against human triple (Del19/T790M/C797S) mutation. Eur J Med Chem. 2023 Sep 27:261:115840.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H31FN8O2S

[ Molecular Weight ]:
538.64

Related Compounds

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