LP-284

Modify Date: 2024-04-05 17:57:18

LP-284 structure	Common Name	LP-284
	CAS Number	2412580-47-1	Molecular Weight	304.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₀N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LP-284

LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL)[1][2].

Name	LP-284

Description	LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
References	[1]. Zhou J, et al. MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S396. [2]. Zhou J, et al. The Positive Enantiomer of a Novel Chiral DNA Alkylating Agent Exhibits Nanomolar Potency in Hematologic Cancers. Blood, 2021, 138: 3991.

Description

LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL)[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

References

[1]. Zhou J, et al. MCL-319 LP-284 - A Highly Potent Small Molecule Targeting Mantle Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S396.

[2]. Zhou J, et al. The Positive Enantiomer of a Novel Chiral DNA Alkylating Agent Exhibits Nanomolar Potency in Hematologic Cancers. Blood, 2021, 138: 3991.