Influenza virus-IN-3

Modify Date: 2024-04-05 18:05:10

Influenza virus-IN-3 Structure
Influenza virus-IN-3 structure
Common Name Influenza virus-IN-3
CAS Number 2412451-16-0 Molecular Weight 456.60
Density N/A Boiling Point N/A
Molecular Formula C25H32N2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Influenza virus-IN-3


Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM[1].

 Names

Name Influenza virus-IN-3

 Influenza virus-IN-3 Biological Activity

Description Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM[1].
Related Catalog
Target

IC50: 0.88 µM (H5N1); 0.10 µM (H5N2); 5.5 µM (H5N6); 0.51 µM (H5N8)[1]

In Vitro Influenza virus-IN-3 (compound 9a) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 118.17, 1442.6, 34543.33, 78.06, 10206, 0.00048, 0.01222 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1].
References

[1]. Ai W, et al. Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors. Eur J Med Chem. 2020 Apr 1;191:112147.

 Chemical & Physical Properties

Molecular Formula C25H32N2O4S
Molecular Weight 456.60