2464415-40-3

2464415-40-3 structure

Name: Influenza A virus-IN-7
Chemical Name: Influenza A virus-IN-7
CAS Number: 2464415-40-3
Molecular Formula: C₂₉H₂₅N₅O
Molecular Weight: 459.54
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2022-07-01 15:21:56
Modify Date: 2025-09-02 11:58:20
Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1].

Name	Influenza A virus-IN-7

Description	Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Inflammation/Immunology
Target	IC50: 3.43 µM (influenza virus); CC50: >100 µM (influenza virus)[1]
In Vivo	Influenza A virus-IN-7 (compound 16r) (1.25 mg/kg for i.v.; 25 mg/kg for p.o.) shows good PK profiles with oral bioavailability of 22.5%[1]. Animal Model: Male SD rats[1] Dosage: 1.25, 25 mg/kg Administration: I.v. or p.o Result: Showed good PK profiles with oral bioavailability of 22.5%.
References	[1]. Zhang G, et al. Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NH-acetamide moieties at C-4. Eur J Med Chem. 2020 Nov 15;206:112706.

Molecular Formula	C₂₉H₂₅N₅O
Molecular Weight	459.54