18-Oxocortisol
Modify Date: 2024-01-03 06:17:47
18-Oxocortisol structure
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Common Name | 18-Oxocortisol | ||
|---|---|---|---|---|
| CAS Number | 2410-60-8 | Molecular Weight | 376.44300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H28O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 18-Oxocortisol18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3]. |
| Name | 17α-Hydroxy-aldosteron |
|---|---|
| Synonym | More Synonyms |
| Description | 18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3]. |
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| Related Catalog | |
| In Vivo | Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3]. |
| References |
| Molecular Formula | C21H28O6 |
|---|---|
| Molecular Weight | 376.44300 |
| Exact Mass | 376.18900 |
| PSA | 111.90000 |
| LogP | 0.96060 |
| Storage condition | -20°C |
| (R)-11,17-Dihydroxy-17-(2-hydroxy-acetyl)-10-methyl-3-oxo-1,2,3,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-13-carbaldehyde |