18-Oxocortisol

Names

[ Name ]:
18-Oxocortisol

[Synonym ]:
(R)-11,17-Dihydroxy-17-(2-hydroxy-acetyl)-10-methyl-3-oxo-1,2,3,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-13-carbaldehyde

Biological Activity

[Description]:

18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor

[In Vivo]

Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3].

[References]

[1]. Nakamura Y, et al. 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primaryaldosteronism. J Clin Endocrinol Metab. 2011 Aug;96(8):E1272-8.

[2]. Ulick S, et al. 18-oxocortisol, a naturally occurring mineralocorticoid agonist. Endocrinology. 1983 Dec;113(6):2320-2.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₈O₆

[ Molecular Weight ]:
376.44300

[ Exact Mass ]:
376.18900

[ PSA ]:
111.90000

[ LogP ]:
0.96060

[ Storage condition ]:
-20°C

Related Compounds

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