HPK1-IN-22

Modify Date: 2024-01-03 17:25:36

HPK1-IN-22 structure	Common Name	HPK1-IN-22
	CAS Number	2380300-79-6	Molecular Weight	462.61
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₀N₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HPK1-IN-22

HPK1-IN-22 (compound ZYF0033) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. HPK1-IN-22 decreases the phosphorylation of SLP76 (serine 376). HPK1-IN-22 promotes anticancer immune responses.HPK1-IN-22 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells in the 4T-1 syngeneic mouse model[1].

Name	HPK1-IN-22

Description	HPK1-IN-22 (compound ZYF0033) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. HPK1-IN-22 decreases the phosphorylation of SLP76 (serine 376). HPK1-IN-22 promotes anticancer immune responses.HPK1-IN-22 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells in the 4T-1 syngeneic mouse model[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP4K Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	HPK1:<10 nM (IC50)
References	[1]. Jingwen Si, et al. Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies. Cancer Cell. 2020 Oct 12;38(4):551-566.e11.

Molecular Formula	C₂₆H₃₀N₄O₂S
Molecular Weight	462.61

HPK1-IN-22

Use of HPK1-IN-22

Names

HPK1-IN-22 Biological Activity

Chemical & Physical Properties