DQP-997-74

DQP-997-74 Structure
DQP-997-74 structure
 Common Name DQP-997-74
CAS Number 2377187-09-0 Molecular Weight 570.37
Density N/A Boiling Point N/A
Molecular Formula C28H19Cl2F2N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DQP-997-74


DQP-997-74 (compound 2i) is a selective inhibitor of N-methyl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0.069 μM and 0.035 μM), with Blood-brain permeability. Where DQP refers to dihydroquinoline-pyrazoline. DQP-997-74 acts synergistically with the agonist glutamate to exhibit time-dependent enhanced potency in inhibiting hypersynchronous activity driven by high-frequency excitatory synaptic transmission. DQP-997-74 reduces the number of epileptogenesis in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 can be used for research on NMDAR-related neurological diseases[1].

 Names

Name DQP-997-74

 DQP-997-74 Biological Activity

Description DQP-997-74 (compound 2i) is a selective inhibitor of N-methyl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0.069 μM and 0.035 μM), with Blood-brain permeability. Where DQP refers to dihydroquinoline-pyrazoline. DQP-997-74 acts synergistically with the agonist glutamate to exhibit time-dependent enhanced potency in inhibiting hypersynchronous activity driven by high-frequency excitatory synaptic transmission. DQP-997-74 reduces the number of epileptogenesis in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 can be used for research on NMDAR-related neurological diseases[1].
Related Catalog
Target

IC50: 0.069 μM (GluN2C), 0.035 μM (GluN2D), 5.2 μM (GluN2A), 16 μM (GluN2B)[1]

References

[1]. D'Erasmo MP, et al. Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor. ACS Chem Neurosci. 2023 Sep 6;14(17):3059-3076..  

 Chemical & Physical Properties

Molecular Formula C28H19Cl2F2N3O4
Molecular Weight 570.37
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Chemsrc provides DQP-997-74(CAS#:2377187-09-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of DQP-997-74 are included as well.>> amp version: DQP-997-74

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