Nardosinone

Modify Date: 2024-01-03 19:33:58

Nardosinone Structure
Nardosinone structure
Common Name Nardosinone
CAS Number 23720-80-1 Molecular Weight 250.333
Density 1.1±0.1 g/cm3 Boiling Point 330.2±32.0 °C at 760 mmHg
Molecular Formula C15H22O3 Melting Point 108-110℃
MSDS N/A Flash Point 142.0±25.2 °C

 Use of Nardosinone


Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances[1].

 Names

Name nardosinone
Synonym More Synonyms

 Nardosinone Biological Activity

Description Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances[1].
Related Catalog
In Vitro Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner. Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway[1].
References

[1]. Li P, et al. Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells.Brain Res Dev Brain Res. 2003 Nov 12;145(2):177-83.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 330.2±32.0 °C at 760 mmHg
Melting Point 108-110℃
Molecular Formula C15H22O3
Molecular Weight 250.333
Flash Point 142.0±25.2 °C
Exact Mass 250.156891
PSA 35.53000
LogP 3.04
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.522
Storage condition 2-8C

 Safety Information

HS Code 29145090

 Synthetic Route

~50%

Nardosinone Structure

Nardosinone

CAS#:23720-80-1

Literature: Archiv der Pharmazie, , vol. 323, # 3 p. 171 - 175

~4%

Nardosinone Structure

Nardosinone

CAS#:23720-80-1

Detail
Literature: Archiv der Pharmazie, , vol. 323, # 3 p. 171 - 175

~50%

Nardosinone Structure

Nardosinone

CAS#:23720-80-1

Literature: Ruecker, Gerhard; Olbrich, Armin Tetrahedron Letters, 1988 , vol. 29, # 37 p. 4703 - 4704

~%

Nardosinone Structure

Nardosinone

CAS#:23720-80-1

Detail
Literature: Archiv der Pharmazie, , vol. 323, # 3 p. 171 - 175

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

Nardosinone
5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
5H-Naphtho[2,1-c][1,2]dioxol-5-one,1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one
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