ROS-generating agent 1

Modify Date: 2024-01-02 20:48:49

ROS-generating agent 1 Structure
ROS-generating agent 1 structure
 Common Name ROS-generating agent 1
CAS Number 2369030-41-9 Molecular Weight 411.34
Density N/A Boiling Point N/A
Molecular Formula C21H15F6NO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ROS-generating agent 1


ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1].

 Names

Name ROS-generating agent 1

 ROS-generating agent 1 Biological Activity

Description ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1].
Related Catalog
References

[1]. Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.  

 Chemical & Physical Properties

Molecular Formula C21H15F6NO
Molecular Weight 411.34
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Chemsrc provides ROS-generating agent 1(CAS#:2369030-41-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ROS-generating agent 1 are included as well.>> amp version: ROS-generating agent 1

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